CLEC7A (Dectin-1) signaling

Dectin-1-Syk-CARD9 Signaling Pathway in TB Immunity

One of the first steps toward mounting an effective immune response to Mycobacterium tuberculosis (Mtb) is recognition of the pathogen through pattern-recognition receptors (PRRs) expressed by innate immune cells. Activation of the PRR Dectin-1 by an unknown mycobacterial ligand triggers an intracellular signaling cascade involving numerous proteins, including spleen tyrosine kinase, protein ki...

Dectin-1 and Dectin-2 in innate immunity against fungi.

Dectin-1 and Dectin-2 are type II transmembrane proteins of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular region. They are expressed mainly in dendritic cells and macrophages. Dectin-1 recognizes β-glucans with its CRD and transduces signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domai...

TLR Signaling and T Cell Responses Cytokine Signaling 1, Thereby Modulating Dectin-1 Stimulation Induces Suppressor of

Arabinoxylan activates Dectin-1 and modulates particulate β-glucan-induced Dectin-1 activation.

SCOPE Arabinoxylan is one of the most commonly consumed dietary fiber. Immunomodulation by arabinoxylan is documented but the mechanisms by which these immune-effects are accomplished are unknown. METHODS AND RESULTS By applying reporter cell lines for Toll-like receptors (TLRs) and Dectin-1, we demonstrated that arabinoxylan interacts with Dectin-1 receptors and not with TLRs. Arabinoxylan a...

Dectin-1 and TLRs Permit Macrophages to